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The Role of Type 2 Cytokines

Type 2 cytokines can produce consistent effects in different diseases.1-6 For example, both IL-4 and IL-13 contribute to the weakening of the epithelial barrier, whether in the skin, the respiratory tract, or the gastrointestinal tract.1-6

Together, Type 2 inflammation and barrier dysfunction associated with IL-4 and IL-13 signaling can lead to abnormal allergic sensitization and increased risk for infection among some of your members.1,3,7,8

Barrier dysfunction:
A common pathology
across diseases1-3

Jak Enzymes and
Cytokines

Type 2 Cytokines in
Different Diseases