Type 2 cytokines can produce consistent effects in different diseases.1-6 For example, both IL-4 and IL-13 contribute to the weakening of the epithelial barrier, whether in the skin, the respiratory tract, or the gastrointestinal tract.1-6
Together, Type 2 inflammation and barrier dysfunction associated with IL-4 and IL-13 signaling can lead to abnormal allergic sensitization and increased risk for infection among some of your members.1,3,7,8

